Conditional transgenic technologies
نویسندگان
چکیده
منابع مشابه
Conditional transgenic technologies.
Transgenic technology has been revolutionised by the development of techniques that allow temporo-spatial control of gene deletion or expression in transgenic animals. The ability to switch gene expression 'on' or 'off' in restricted tissues at specific times allows unprecedented flexibility for exploring gene function in both health and disease. As use of these techniques grows in all areas of...
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Alexander C. Jackson, Chen Liu, Makoto Fukuda, Michael Lazarus and Laurent Gautron* 1 Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT, USA 2 Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA 3 Baylor College of Medicine, Childrens Nutrition Research Ct, Houston, TX, USA 4 Internat...
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Recent progress in the development of molecular genetic methods enables the manipulation of genes in intact mammalian organisms. The power of such techniques to elucidate complex biological systems was initially recognized and exploited by developmental biologists and immunologists. More recently, the utility of these approaches for examining neural gene function in the context of the intact or...
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Gene transfer technologies in mammals are the focus of renewed interest owing to the recent emphasis on analyzing gene function in the postgenomic era. Three important developments in this area include transgenics, gene targeting and nuclear transfer or animal cloning. These technological innovations have enhanced our ability to analyze gene function at the level of the whole organism and have ...
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Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant, polyglutamine-induced neurodegenerative disorder that results in loss of motor coordination caused primarily by a disruption of cerebellar Purkinje cell function. In this study, we developed a conditional SCA1 mouse model to examine whether stopping expression of mutant ataxin-1 alters the disease phenotype. After cessation of SCA1[...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2001
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.0.1710001